Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nr5a1  nuclear receptor subfamily 5, group A, member 1   (Synonyms: Ad4BP, adrenal 4-binding protein, ELP, Ftzf1, Ftz-F1, SF1, SF-1, steroidogenic factor 1)
Results	Reference
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1*	J:146199 Barrionuevo F, Georg I, Scherthan H, Lecureuil C, Guillou F, Wegner M, Scherer G, Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Dev Biol. 2009 Mar 15;327(2):301-12
1	J:189958 Buaas FW, Gardiner JR, Clayton S, Val P, Swain A, In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development. 2012 Dec;139(24):4561-70
1	J:188254 Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honore A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J, The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
1	J:237198 Burton RF, Relationships among fat mass, fat-free mass and height in adults: A new method of statistical analysis applied to NHANES data. Am J Hum Biol. 2017 May 6;29(3)
1	J:99227 Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ, PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol. 2005 Jul;19(7):1893-903
1*	J:193956 Cheung CC, Kurrasch DM, Liang JK, Ingraham HA, Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. J Comp Neurol. 2013 Apr 15;521(6):1268-88
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:253696 Feng S, Xing C, Shen T, Qiao Y, Wang R, Chen J, Liao J, Lu Z, Yang X, Abd-Allah SM, Li J, Jing N, Tang K, Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Sci Rep. 2017 Jul 13;7(1):5282
1	J:168522 Huang CC, Miyagawa S, Matsumaru D, Parker KL, Yao HH, Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog. Endocrinology. 2010 Mar;151(3):1119-28
1*	J:163555 Huang CC, Yao HH, Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary. BMC Dev Biol. 2010;10:66
1	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
1	J:310001 Ikeda Y, Tagami A, Komada M, Takahashi M, Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary during Embryonic and Postnatal Development and in Adulthood. Neuroendocrinology. 2017;105(4):357-371
1	J:227422 Karpova T, Ravichandiran K, Insisienmay L, Rice D, Agbor V, Heckert LL, Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83
1	J:56540 Kawabe K, Shikayama T, Tsuboi H, Oka S, Oba K, Yanase T, Nawata H, Morohashi K, Dax-1 as one of the target genes of Ad4BP/SF-1. Mol Endocrinol. 1999 Aug;13(8):1267-84
1	J:138575 Kim AC, Reuter AL, Zubair M, Else T, Serecky K, Bingham NC, Lavery GG, Parker KL, Hammer GD, Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development. 2008 Aug;135(15):2593-602
1	J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
1	J:199078 Langlais D, Couture C, Kmita M, Drouin J, Adult pituitary cell maintenance: lineage-specific contribution of self-duplication. Mol Endocrinol. 2013 Jul;27(7):1103-12
1	J:319655 Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A, FEAT enhances INSL3 expression in testicular Leydig cells. Genes Cells. 2018 Nov;23(11):952-962
1*	J:333151 Lin YF, Schang G, Buddle ERS, Schultz H, Willis TL, Ruf-Zamojski F, Zamojski M, Mendelev N, Boehm U, Sealfon SC, Andoniadou CL, Bernard DJ, Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells. Endocrinology. 2022 Oct 11;163(11)
1	J:274694 Lodge EJ, Santambrogio A, Russell JP, Xekouki P, Jacques TS, Johnson RL, Thavaraj S, Bornstein SR, Andoniadou CL, Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade. Elife. 2019 Mar 26;8:e43996
1	J:193919 Lu F, Kar D, Gruenig N, Zhang ZW, Cousins N, Rodgers HM, Swindell EC, Jamrich M, Schuurmans C, Mathers PH, Kurrasch DM, Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
1	J:306212 Ma T, Wong SZH, Lee B, Ming GL, Song H, Decoding neuronal composition and ontogeny of individual hypothalamic nuclei. Neuron. 2021 Apr 7;109(7):1150-1167.e6
1	J:269227 Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calmejane MA, Boeva V, Tauveron I, Lefrancois-Martinez AM, Martinez A, Val P, Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274
1	J:81356 Meeks JJ, Crawford SE, Russell TA, Morohashi K, Weiss J, Jameson JL, Dax1 regulates testis cord organization during gonadal differentiation. Development. 2003 Mar;130(5):1029-36
1*	J:53330 Morohashi K, Tsuboi-Asai H, Matsushita S, Suda M, Nakashima M, Sasano H, Hataba Y, Li CL, Fukata J, Irie J, Watanabe T, Nagura H, Li E, Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Blood. 1999 Mar 1;93(5):1586-94
1*	J:175980 Mortensen AH, MacDonald JW, Ghosh D, Camper SA, Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics. 2011 Oct 6;43(19):1105-16
1	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1	J:179464 Paul A, Laufer E, Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):133-40
1	J:82562 Pulichino AM, Vallette-Kasic S, Tsai JP, Couture C, Gauthier Y, Drouin J, Tpit determines alternate fates during pituitary cell differentiation. Genes Dev. 2003 Mar 15;17(6):738-47
1	J:79850 Raetzman LT, Ward R, Camper SA, Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development. 2002 Sep;129(18):4229-39
1	J:290205 Richardson N, Gillot I, Gregoire EP, Youssef SA, de Rooij D, de Bruin A, De Cian MC, Chaboissier MC, Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals. Elife. 2020 May 26;9:e53972
1	J:308864 Rotgers E, Nicol B, Rodriguez K, Rattan S, Flaws JA, Yao HH, Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice. FASEB J. 2021 Aug;35(8):e21770
1	J:325352 Sahut-Barnola I, Lefrancois-Martinez AM, Dufour D, Botto JM, Kamilaris C, Faucz FR, Stratakis CA, Val P, Martinez A, Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome. J Invest Dermatol. 2022 May 12;
1	J:277704 Shima Y, Miyabayashi K, Haraguchi S, Arakawa T, Otake H, Baba T, Matsuzaki S, Shishido Y, Akiyama H, Tachibana T, Tsutsui K, Morohashi K, Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes. Mol Endocrinol. 2013 Jan;27(1):63-73
1	J:272573 Shima Y, Miyabayashi K, Sato T, Suyama M, Ohkawa Y, Doi M, Okamura H, Suzuki K, Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells. Development. 2018 Dec 5;145(23):dev169136
1	J:73774 Suh H, Gage PJ, Drouin J, Camper SA, Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development. 2002 Jan;129(2):329-37
1	J:115933 Suh JM, Yu CT, Tang K, Tanaka T, Kodama T, Tsai MJ, Tsai SY, The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006 Dec;20(12):3412-20
1	J:83384 Tran PV, Lee MB, Marin O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA, Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci. 2003 Apr;22(4):441-53
1	J:108374 Vesper AH, Raetzman LT, Camper SA, Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology. 2006 Apr;147(4):1654-63
1	J:204972 Wood MA, Acharya A, Finco I, Swonger JM, Elston MJ, Tallquist MD, Hammer GD, Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus. Development. 2013 Nov;140(22):4522-32